Mefloquine, commonly known by its brand name Lariam, is a medication used to prevent and treat malaria. Developed in the 1970s, it is on the World Health Organization's List of Essential Medicines. Mefloquine has been controversial due to its potential side effects, including vivid dreams, anxiety, psychosis, and seizures. The true story behind this antimalarial drug unfolds a complex narrative involving military use, concerns about neuropsychiatric adverse effects, discussions about risk management and patient information, regulatory actions, and debates about the balance between efficacy and safety. Understanding the journey of mefloquine sheds light on the intricate world of drug development, regulation, and the ongoing efforts to combat infectious diseases.
